4th Century

00s
- 303
  - St. Lucian, a priest and martyr, undertook a new (seventh) edition of the Old Testament from Hebrew into Greek under Emperor Diocletian
  - Maximian and Diocletian ordered by edict that the books of Moses and other Sacred Scripture be surrendered for burning; many faithful resisted and obtained the laurel of martyrdom
- 304
  - Death of St. Saturninus (approximate date)
  - Death of St. Vincent
- 305
  - Birth of Pope Damasus I (approximate date)
- 306
  - Birth of St. Ephrem the Syrian (approximate date)
- 309
  - Death of St. Menas (approximate date)
- 400
  - Birth of St. Leo the Great (approximate date)
10s
- 310
  - Birth of Epiphanius (approximate date)
  - Birth of St. Hilary of Poitiers (approximate date)
  - Death of Maximian
- 311
  - Death of Diocletian
- 312
  - Death of St. Lucian
- 313
  - Birth of Didymus the Blind (approximate date)
- 314
  - Birth of Libanius (approximate date)
20s
- 322
  - Birth of Proba Falconia (approximate date)
- 325
  - Death of Iamblichus (approximate date)
  - Death of Lactantius (approximate date)
- 328
  - Birth of Emperor Valens
- 329
  - Birth of St. Gregory Nazianzen (approximate date)
30s
- 330
  - Birth of St. Basil the Great (approximate date)
- 331
  - Birth of Julian the Apostate
- 332
  - Birth of St. Monica (approximate date)
- 335
  - Birth of St. Gregory of Nyssa (approximate date)
- 336
  - Death of Arius
- 337
  - Birth of St. Zenobius (approximate date)
40s
- 340
  - Birth of St. Ambrose of Milan (approximate date)
  - Death of Eusebius of Caesarea
- 342
  - Birth of St. Jerome (approximate date)
- 345
  - Birth of Rufinus of Aquileia (approximate date)
- 347
  - Birth of Emperor Theodosius
  - Birth of St. John Chrysostom (approximate date)
- 349
  - Death of Basil the Elder (approximate date)
50s
- 354
  - Birth of St. Augustine of Hippo
  - Birth of St. Paulinus of Nola (approximate date)
- 356
  - Death of St. Antony the Great
60s
- 360
  - Birth of John Cassian (approximate date)
- 363
  - Birth of Palladius (approximate date)
  - Death of Julian the Apostate
- 367
  - Death of St. Hilary of Poitiers
70s
- 370
  - Birth of Macrobius (approximate date)
  - Death of Proba Falconia (approximate date)
- 373
  - Death of St. Athanasius of Alexandria
  - Death of St. Ephrem the Syrian
- 375
  - Death of Emmelia (approximate date)
- 376
  - Birth of St. Cyril of Alexandria (approximate date)
  - Death of Photinus
- 378
  - Death of Emperor Valens
- 379
  - Death of St. Basil the Great
80s
- 380
  - Birth of Socrates Scholasticus (approximate date)
- 384
  - Death of Pope Damasus I
- 387
  - Death of St. Marcian (approximate date)
  - Death of St. Monica
- 388
  - Birth of St. Simeon the Stylite (approximate date)
90s
- 390
  - Death of Diodorus of Tarsus (approximate date)
  - Death of St. Gregory Nazianzen
- 393
  - Birth of Theodoret of Cyrrhus (approximate date)
  - Death of Libanius (approximate date)
- 395
  - Death of Emperor Theodosius
  - Death of St. Gregory of Nyssa (approximate date)
- 397
  - Death of Philastrius (approximate date)
  - Death of St. Ambrose of Milan
- 398
  - Death of Didymus the Blind